中科院百人计划终期评估优秀，享受国务院政府特殊津贴。Evolution、Quantitative Biology、BMC Genomics等期刊编委。在国内外学术刊物上发表论文60余篇，参编专著2部，授权国家专利4项，软件著作权10项。研究领域为群体遗传学与计算基因组学，从构建数学模型、发展统计方法和分析基因组数据三个维度开展研究。目前的研究方向包括：复杂表型与疾病的遗传与适应性进化机制；分子表型刻画（预测）；法医基因组智能算法。

1. Ji X#, Chi L#, Wu L#, Chen J, Yan A, Li Y, Tu Z, Ye J, Chen H*. SMART: STR mixture profile analysis and resolution tools. Forensic Science International: Genetics. 2025. 74(2025):1031418.

2. Zhang X#, Ji X#, Wang L#, Chi L, Li C*, Wen S*, Chen H*. STRsensor: A computationally efficient method for STR allele-typing from massively parallel sequencing data. Briefings in Bioinformatics. 2025. 26(1):bbae637.

3. Chi L#, Dong Y#, Wang R#, Yang S#, Wu L#, Xue Y*, Chen H*. HapNetworkView: A tool for haplotype network exploration and visualization. BMC Genomics. 2025. 26(1):52.

4. Chi L#, Zhang X#, Xue Y*, Chen H*. FastHaN: a fast and scalable program for constructing haplotype network. Molecular Ecology Resources. 2025. 25(5), e13829.

5. Pan C#, Hou Y#, Hou Y#, Wang R#, Qian M, Bai X, Liang M, Wang J, Liu J, Wei Q, Pan Z, Wang T, Hu C, Xiang K, Yang C, Wang C*, Chen H*, Zhang J*. Integrated analysis reveals that miR-548b promotes the development of obesity and T2DM. Journal of Genetics and Genomics. 2025. 52(2025):231-244.

6. Wu J, Chen H*. 3D head pose estimation via normal maps: a generalized solution for depth image, point cloud and mesh. Advanced Intelligent Systems. 2024. 6:2400159.

7. Zhao S#, Chi L#, Fu M, Chen H*. HaploSweep: Detecting and distinguishing soft and hard sweeps through haplotype structure. Molecular Biology and Evolution. 2024. 41(10):msae192.

8. Zhao S#, Chi L#, Chen H*. CEGA: a method for inferring natural selection by comparative population genomic analysis across species. Genome Biology. 2023. 24, 219.

9. Zhao S#, Sha T#, Xue Y*, Chen H*. Flattening the curve: Imperative when China eases the severe COVID-19 control policy. Journal of Infection. 2023. 86(2023): e75-e77.

10. Luo H#, Zhang P#, Zhang W, Zheng Y, Hao D, Si Y, Niu Y, Song T, Li T, Zhao S, Chen H*, Xu T*, He S*. Recent positive selection signatures reveal phenotypic evolution in the Han Chinese population. Science Bulletin. 2023. 68(2023): 2391-2404.  

11. Jia H#, Sha T#, Zhao S#, Su W#, Liu P#, Zhen R#, Li P, Zhou L, Xu Y, Wen Y, Chi L, Di B, Li P*, Chen H*, Qin Z*. Genomic and epidemiological perspectives on the first local sporadic cases of Mpox in China. Emerging Microbes & Infections. 2023. 12(2): 2245932. doi: 10.1080/22221751.2023. 2245932.  

12. Zhang X#, Liu Q#, Zhang H#, Zhao S#, Huang J, Sovannary T, Bunnath L, Aun HS, Samnom H, Su B*, Chen H*. The distinct morphological phenotypes of Southeast Asian aborigines are shaped by novel mechanisms for adaptation to tropical rainforests. National Science Review. 2022. 9(3):nwab072.

13. Hou Y#, Zhao S#, Liu Q#, Zhang X#, Sha T, Su Y, Zhao W, Bao Y, Xue Y*, Chen H*. Ongoing positive selection drives the evolution of SARS-CoV-2 genomes. Genomics Proteomics Bioinformatics. 2022. 20:1214-1223.

14. Liu J#, Ji X#, Chen H*. Beta-PSMC: Uncovering more detailed population history using beta distribution. BMC Genomics. 2022.

15. Zhao S#, Hou Y#, Zhang X#, Hughes A, Liu N, Peng M, Wang Q, Xue Y*, Chen H*. Pinpointing the animal origins of SARS-CoV-2: a genomic approach. Journal of Genetics and Genomics. 2022. 49(9):900-902.

16. Ji X, Chi L, Xu Z, Peng Z, Ye J, Tu Z*, Chen H*. SMART: an analysis system for mixed STR profiles. Forensic Science and Technology. 2022. 47(1):1-9. DOI：

17. Zhao S, Sha T, Wu CI*, Xue Y*, Chen H*. Will the large-scale vaccination succeed in containing the COVID-19 pandemic and how soon? Quantitative Biology. 2021. 9(3): 304-316. DOI:10.15302/J-QB-021-0256 

18. Zhao S, Chen H*. Modeling the epidemic dynamics and control of COVID-19 outbreak in China. Quantitative Biology. 2020; 8(1):11-19.

19. Lyu J#, Huang L#, Zhang S, Zhang Y, He W, Zeng P, Zeng Y, Huang G, Zhang J, Ning M, Bao Y, Zhao S, Fu Q, Wade LJ*, Chen H*, Wang W*, Hu F*. Neo-functionalization of a Teosinte branched 1 homologue mediates adaptations of upland rice. Nature Communications. 2020 Feb 5;11(1):725.

20. Zhao S＃, Zhang T＃, Liu Q, Wu H, Su B, Shi P, Chen H*. Identifying Lineage-Specific Targets of Natural Selection by a Bayesian Analysis of Genomic Polymorphisms and Divergence from Multiple Species. Molecular Biology and Evolution. 2019. 36(6):1302-1315.

21. Chen H*. A Computational Approach for Modeling the Allele Frequency Spectrum of Populations with Arbitrarily Varying Size. Genomics Proteomics Bioinformatics. 2019; 17(6):635-644.

22. Zhao S＃, Shi CM＃, Ma L＃, Liu Q, Liu Y, Wu F, Chi L, Chen H*. AIM-SNPtag: A computationally efficient approach for developing ancestry-informative SNP panels. Forensic Science International: Genetics. 2019 Jan 38:245-253.

《中国生物信息学2035发展战略》(编写组成员) 科学出版社，2024

《医学遗传学》(编委成员) 科学出版社，2020

  专利：一种混合DNA图谱的分析方法。中国，202210100696.X.

软件：罕见病辅助诊疗系统V1.0（2024SR0456178）2024

软件：一种高效构建单倍型网络软件（2022SR1080266）2022

软件：全球新冠肺炎疫情监测与预测系统V1.0 （2022SR1451735） 2022

软件：法医DNA 混合图谱解析系统V1.0（2021SR0583583），2021

2023年

  成果“SMART：法医混合 DNA 图谱智能解析系统”入选 2023 年中关村论坛国际技术交易大会“百项国际新技术新产品榜单”

2021年

  “抗击新冠疫情与溯源全国先进集体”（成员）

2020年

  入选“享受国务院政府特殊津贴”专家

2019年

 中国科学院“百人计划”终期评估优秀